Reverse-T3

Reverse-T3

T4 can be compared to a key that has not yet been cut by a locksmith to fit in the lock (the thyroid receptor site). When it is cut properly (as T3), it fits in the lock and opens the door. The reverse-T3 stereoisomer of T3 is mirror image of the active T3 molecule – a key that is cut differently enough by the locksmith that it fits in the lock (receptor site) yet doesn't open the door. When there is an excess of reverse-T3, no thyroid metabolism is stimulated [Source: Martin Milner].

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