TREATMENT: THE PROTOCOL

TREATMENT: THE PROTOCOL

• Metabolism of GUAIFENESIN

It is quickly absorbed from the gastrointestinal tract, and is rapidly metabolized and excreted in the urine. The half-life of GUAIFENESIN is 1 hour. The term Long-acting or Quick-acting capsules or tablets refer to how rapidly a dose of GUAIFENESIN is released into our system, not to the GUAIFENESIN itself.

The metabolism of GUAIFENESIN may have variations from an individual to another. Certain health conditions may as well slow down this metabolism.

• Side effects

GUAIFENESIN has already been used for years on thousands of patients, and a great many take it since more than twenty years. No side effects have been reported.

• GUAIFENESIN's effectiveness

I see every day people diagnosed with fibromyalgia which have been told that they must learn to live with these health problems. Fortunately, this is no longer the case for most individuals using GUAIFENESIN.

Although no treatment or therapy is 100 % effective in all cases, it has been my experience since twelve years, and the experience of dozens of doctors around the world since more than two decades, that GUAIFNESIN, when taken correctly, helps the vast majority of people suffering from fibromyalgia to recover a normal life or an almost normal life.

According to the phosphate retention theory, taking GUAIFENESIN stops the accumulation of phosphates in the body cells by acting on the kidneys in a way that helps the phosphates excretion. It takes time to eliminate all the phosphates that have been stored in the body over a person's lifetime: less time for young ones, more time the older the person is.

Characteristics of the treatment:

Taking GUAIFENESIN does not suddenly make the symptoms disappear;

GUAIFENESIN works slowly;

For most people it will take a few weeks to reach the effective dose;

There is a narrow dose at which GUAIFENESIN works for each individual

In most instances, once the proper dose is reached, while most people will experience significant improvement within several weeks to several months, complete recovery may take longer depending on how long the disorders were present. As a result of improved kidney function from GUAIFENESIN, it is theorized that every two months of taking GUAIFENESIN eliminates approximately one year of phosphate intracellular storage. Some people are quick responders and others are long responders. If the patient is a quick responder, the respond is a dramatic improvement in a short time;

Patience and perseverance are the two key words: the longer GUAIFENESIN is used, the greater the long-term improvement becomes;

10 to 15 % of people using GUAIFENESIN may not respond at all. It is not known why;

GUAIFENESIN is a life time treatment. GUAIFENESIN appears to be altering some aspect of the underlying cause of the disease which essential part is genetic. No genetic treatment is available. As GUAIFENESIN does not restore proper function permanently, maintaining one's therapeutic dose is the only way to prevent symptoms from recurring;

It's a safe and an inexpensive treatment.

• Required steps to using GUAIFENESIN successfully

Those who think that recovery requires nothing more than swallowing a pill, GUAIFENESIN may not be for them. The success of the treatment requires an active role of the patient, and depends upon his constant application of essential steps.

1) Elimination of all sources of salicylates

There are many types of salicylates (from aspirin): some are manufactured and some are from natural plant sources. Plants produce varying amounts of salicylates stored in barks, leaves, roots and seeds as a way to defend themselves from soil bacteria and fungus. Salicylates from both natural and synthetic sources put on our skin, scalp, lips, or gums will readily enter the bloodstream, and soon come into contact with the same special receptor sites in the proximal tubules of the kidneys that are needed for GUAIFENESIN to work. Because the molecules of salicylates bind more easily to those receptors than the molecules of GUAIFENESIN, the presence of even small amounts of salicylates will block GUAIFENESIN's action.

Before starting the treatment it is essential to avoid all types of salicylates for GUAIFENESIN to be effective. Most toothpaste, dental hygiene and gum care products, chewing gum, sunscreen, makeup, lotions cosmetics, and other toiletries, as well supplements, medicinal herbs, and some medications are likely to block unless you are careful to choose the appropriate salicylates-free products.

In my clinic you will not be left to yourself in search of salicylates, we will help you step by step, with a magnifying glass if needed.

There is no compromise. Failure to completely eliminate salicylates is the main reason for treatment failure.

Mapping the lumps and bumps will detect a salicylate blockage. A mapping is done at each consultation. From time to time, companies may change some ingredients in the existing products without letting you known. In my clinic we are up to date.

Let me remind that in the presence of salicylates, GUAIFENESIN will still liquefy mucus against cold and coughing because to this effect other receptors are concerned.

◊The salicylate sensitivity

Avoiding salicylates may be very useful to individuals suffering from what is called salicylate sensitivity. Its existence has been proved on many asthmatics, particularly those with allergic asthma or asthma associated with allergies, as well on people suffering from chronic sinusitis. The sensitivity to aspirin is due to a hyperproduction of leukotrienes by salicylates, substances known to create inflammation, bronco-constriction, and pains. Since many fibromyalgics suffer also from asthma, sinus troubles and allergies, they may be as well salicylate sensitive, and therefore would benefit from avoiding them.

◊ The salicylates could block vitamin K

Avoiding salicylates, fibromyalgics could raise their level of vitamin K from which they would get some benefit.

Decreased vitamin K levels are often found in fibromyalgics, responsible for frequent spontaneous bruises or after a light shock.

Vitamin K reduces the level of IL-6, one of the many inflammatory cytokines that Dr. St. Amand and his team have found elevated in fibromyalgia, and to which they attribute a role in the immune potential of the disease. We have previously mentioned their researches proving that taking GUAIFENESIN normalize most of these cytokines.

Vitamin K is also anti-oxydant, controls insulin liberation, and plays a role in protecting osteoporosis.

◊Salicylates and thyroid hormones

It has been proved that salicylates reduce the thyroid hormones free level in the blood

by binding them to proteins. Since hypothyroidism is often found in fibromyalgics, avoiding salicylates would help them to normalize their thyroid function, together with a hormonal adapted treatment.

Thus, avoiding salicylates to fibromyalgics not only allows GUAIFENESIN to work on the kidneys, but combines other beneficial effects.

2) A diet against hypoglycemia

The syndrome of hypoglycemia may be induced or intensified by fibromyalgia.  Approximately 40% of female and 20% of male fibromyalgics have hypoglycemia or carbohydrate intolerance. The combination of both conditions is called FIBROGLYCEMIA. Fibromyalgia and hypoglycemia go hand to hand. Symptoms of hypoglycemia overlap or mimic those of fibromyalgia.

Following an appropriated diet is essential. Diet is an individual matter. Precise explanation will be given in my clinic and answer to any question. Symptoms of hypoglycemia, relation towards food and objective feelings after a meal made with sweets or starchs will be precisely looked upon.

Acute hypoglycemic symptoms are easy to identify.

They generally occur within three or four hours after eating, and are also common in the middle of the night: panic attacks, shaking of the hands or body, sudden onset of sweating and sensation of imperious hunger, headaches, heart palpitations or rhythm irregularities, severe anxieties, dizziness or syncope. However, not all acute symptoms occur in every patient with hypoglycemia.

The chronic hypoglycemic symptoms are more generalized ones. These are symptoms which may be present all the time irrespective of the blood sugar level. They occur not from sudden falls of blood sugar and the counterregulatory hormones, but from the metabolic fatigue caused by hypoglycemia. Headaches are felt like a low rubber band around the head. As well, fatigue, irritability, nervousness, flushing, ringing in hears, impaired memory and concentration, tight muscles, pins and needles in hands and feet, abdominal pain, bloating, gas, and diarrhea.

It should be pointed out that the patient may notice that eating relieves the symptoms while there is an exacerbation with hunger.

Most fibromyalgics repetitively yield to their carbohydrate craving throughout the day in a futile attempt to produce energy. Since sugars and starches are quickly converted to glucose in the process of digestion, the body prefers them for fuel. Unfortunately, for the carbohydrate-craving fibromyalgics, each supply quickly saturates their systems with glucose molecules that cause the pancreas to release large amount of insulin. Insulin surges lower the blood sugar by driving it mainly into muscles, but also into fat cells, the liver, and most other areas of the body. In addition, and that is our particular concern, insulin causes an increase in renal reabsorbtion of phosphate, and also drives it into various cells; therefore, frequent releases of insulin will intensify the symptoms of fibromyalgia. The symptoms of hypoglycemia are then compounded with those of fibromyalgia, and the result further aggravates the fibromyalgia. Those patients face a serious metabolic problem. Dietary modification becomes essential. There can be no compromise, otherwise their symptoms will be exacerbated even if GUAIFENESIN works efficiently. Hypoglycemia and fibromyalgia go hand to hand, they must be treated concurrently. Elimination of sugar and starches prevents the wide fluctuations of blood sugar, and subsequently the noxious insulinic peaks. (click for more)

Some patients require to begin with a strict diet, others with a more liberal one. A strict diet should not exceed two months, after which will succeed a liberal diet. Once you discover the beneficial effects of the diet, it becomes a way of life.

It is important to note that there are no restrictions on diet, unless there is fibroglycemia.

3) Finding the proper dosing of GUAIFENESIN

The treatment requires to follow a special protocol and regular medical examinations. The goal is to find the minimal effective dose that will reverse the course of the disease. Fibromyalgia is genetically determined, as well is GUAIFENESIN's respond, i.e. the therapeutic dose depends on the severity of the genetic disorder. In one family of fibromyalgics the effective dose is the same for each individual. Some people are "quick responders", some are "slow responders".

The ideal dose is individual, and reached gradually, taking notice of phases of exacerbation and improvement.

GUAIFENESIN's action on the kidneys will allow phosphates from affected body cells to flow to the filters of the kidneys. Even if the kidneys are now working to their best due to GUAIFENESIN's action, they will be unable to respond straight away to a massive and rapid purge coming from multiple fibromyalgics sites. The blood will catch some phosphates back and bring them anywhere in the body, causing temporarily and bearable exacerbation of symptoms, while others will be improved.      

An extremely gradual dosing pattern improves chances of quickly finding the optimum dose and minimizing unnecessary exacerbations. Too little GUAIFENESIN results in no apparent improvement, and too much makes one feel consistently worse. Short periods of bearable exacerbation of symptoms (a few hours to a few days) will alternate with longer and longer periods of improvement (a few weeks to a few months).

I ask my patients to monitor every day symptoms changes. Together with regular "mappings" these are the most accurate ways to find the ideal dose.

How a person experiences recovery using GUAIFENESIN varies from a person to another, depending on first elimination of minor or major symptoms. General well-being will appear progressively in most patients. More ancient is the disease more time it takes for complete recovery. Recent symptoms improve first, last to improve are ancient ones. Some deep and ancient lesions may be irreversible.

4) Mapping: an important step

The "mapping" is an objective procedure that helps for diagnosis and determination of the effective dose of GUAIFENESIN. It will be done before commencing therapy, and all times during the treatment, since changes are subtle. This simple examination of lumps and bumps will suggest that recovery is proceeding. Lumps and bumps should get progressively smaller, softer, or more mobile. Some time in the future, the lumps and bumps so graphically illustrated on the first map will be just a memory.

Mapping can also detect the presence of a salicylate block.

5) Find a trained doctor to the GUAIFENESIN protocol

You have learnt by now that simply taking an arbitrary amount of GUAIFENESIN on a daily basis is unlikely to produce symptomatic improvements. Only a physician formed to the protocol gets the maximum success. It requires therapeutic steps of salicylates avoidance, carbohydrate diet if needed, proper dosing, and mapping. And most but not least, it requires a devoted doctor.

One has to know that:

 There is no one-size-fits-all solutions because each case is different;

Looking for the ideal dose needs time and faces ups and downs;

 What works for an individual doesn't necessarily work for another individual;

 Fibromyalgia is often associated with undiagnosed conditions;

Others conditions have to be taken in count, such as thyroid troubles, adrenal deficiency, and other hormone imbalance that may occur at any age, but mostly around the menopause;

Side effects of many medicines can mimic muscle or articular pain and fatigue of fibromyalgia.

I can state that GUAIFENESIN is effective for the majority of people, and poor results are much more likely the result of confusion regarding salicylates, inappropriate dosage, and often a lack of patience. Complete recovery takes time. Patience and perseverance are the two key words. Unfortunately, there are people who have used GUAIFENESIN in the past but discontinued its use due to lack of patience. Curiously, those are the same people who carried on for years inefficacious therapies.

norkurld@zahav.net.il
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